Placenta Accreta Spectrum Novel Diagnostic Signs and Management

Abstract

Placenta accreta spectrum (PAS) is a potentially life-threatening pregnancy condition characterized by abnormal placental adherence and failure of normal placental separation at delivery. Classical imaging signs, such as placental lacunae, loss of the retroplacental clear zone, myometrial thinning, and an abnormal uterine–bladder interface, have long been used in clinical practice. However, these conventional markers may not always provide sufficient sensitivity or specificity, particularly in early gestation or in subtle cases. Recent research has focused on identifying novel imaging, biochemical, and clinical indicators that may improve diagnostic accuracy. Early and accurate diagnosis allows obstetricians to plan delivery in specialized centers equipped with multidisciplinary teams. Women with suspected or confirmed PAS should be managed in specialized referral centers with an experienced multidisciplinary team and appropriate resources for complex pelvic surgery and major obstetric hemorrhage.