An Overview on Jejunal Ischemia-Reperfusion Injury and The Promising role of Mesenchymal Stem Cell-Derived Microvesicles

Abstract

Intestinal ischemia-reperfusion (I/R) injury is a serious pathological condition resulting from temporary interruption of blood supply followed by restoration of circulation, which leads to oxidative stress, inflammatory responses, and severe mucosal damage. The jejunum is particularly susceptible to ischemic injury due to its high metabolic demand and complex vascular supply. Recently, regenerative and immunomodulatory therapies have gained increasing attention for reducing tissue injury and enhancing intestinal recovery. Mesenchymal stem cell-derived microvesicles (MSC-MVs) represent a promising cell-free therapeutic strategy due to their ability to transfer bioactive molecules that regulate inflammation, apoptosis, and tissue repair.